Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity
نویسندگان
چکیده
منابع مشابه
Differentially expressed late constituents of the epidermal cornified envelope.
Barrier activity of skin and internal barrier-forming epithelial linings are conferred by a lipid-corneocyte structure (stratum corneum in skin). The integrity of the corneocytes depends on the outer cornified envelope and is essential for maintenance of barrier function. During epidermal development and differentiation, proteins are sequentially incorporated into the envelope via action of epi...
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Recently, it has been shown that the small description logic (DL) EL, which allows for conjunction and existential restrictions, has better algorithmic properties than its counterpart FL0, which allows for conjunction and value restrictions. Whereas the subsumption problem in FL0 becomes already intractable in the presence of acyclic TBoxes, it remains tractable in EL even with general concept ...
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The majority of retroviral envelope glycoproteins characterized to date are typical of type I viral fusion proteins, having a receptor binding subunit associated with a fusion subunit. The fusion subunits of lentiviruses and alpha-, beta-, delta- and gammaretroviruses have a very conserved domain organization and conserved features of secondary structure, making them suitable for phylogenetic a...
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We consider the consequences on basic reasoning problems of allowing negated primitive concepts on left-hand-sides of inclusion dependencies in the description logic dialect CFDnc. Although earlier work has shown that this makes CQ answering coNP-complete, we show that TBox consistency and concept satisfiability remain in PTIME. We also show that knowledge base consistency and instance retrieva...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.08.026